%PDF-1.6%???? 193 0 obj <> endobj 192 0 obj <>stream doi:10.1158/1078-0432.CCR-19-0916 application/pdf Treatment with Humanized Selective CD19CAR-T Cells Shows Efficacy in Highly Treated B-ALL Patients Who Have Relapsed after Receiving Murine-Based CD19CAR-T Therapies 10.1158/1078-0432.CCR-19-0916 http://dx.doi.org/10.1158/1078-0432.CCR-19-0916 2019-8-7 false 10.1158/1078-0432.CCR-19-0916 psychoceramics.org societyofpsychoceramics.org 10.1158/1078-0432.CCR-19-0916 2019-8-7 false psychoceramics.labs.crossref.org Acrobat Distiller 8.1.0 (Windows) Arbortext Advanced Print Publisher 9.1.406/W Unicode 2019-08-09T06:19:32-07:00 2019-08-07T12:20:59+05:30 2019-08-09T06:19:32-07:00 uuid:60f19b9a-1dd2-11b2-0a00-8f08275d5100 uuid:60f19b9d-1dd2-11b2-0a00-c90000000000 endstream endobj 191 0 obj <> endobj 186 0 obj <> endobj 55 0 obj <> endobj 3 0 obj <> endobj 146 0 obj <> endobj 145 0 obj <>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Type/Page>> endobj 150 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Type/Page>> endobj 151 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Type/Page>> endobj 195 0 obj <>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>> endobj 208 0 obj [214 0 R 215 0 R 216 0 R 217 0 R 218 0 R 219 0 R] endobj 209 0 obj <>stream q 539.3594055 0 0 83.3014526 22.3202972 650.6985474 cm /Im0 Do Q BT /T1_0 1 Tf 10 0 0 10 105.56998 516.99979 Tm ( Published OnlineFirst July 12, 2019.)Tj /T1_1 1 Tf -7.557 0 Td (Clin Cancer Res\240)Tj /T1_0 1 Tf 0 1 TD (\240 )Tj 0 1.00001 TD (Yu Zhao, Zhongfeng Liu, Xuan Wang, et al. )Tj /T1_2 1 Tf 0 1 TD (\240 )Tj /T1_3 1 Tf 18 0 0 18 30 556.99991 Tm (Therapies)Tj T* (Relapsed after Receiving Murine-Based CD19CAR-T)Tj T* (Shows Efficacy in Highly Treated B-ALL Patients Who Have )Tj 0 1.00001 TD (Treatment with Humanized Selective CD19CAR-T Cells)Tj ET 30 422 524 75 re 0 0 m S BT /T1_0 1 Tf 11 0 0 11 120.94202 469.99997 Tm (\240 )Tj /T1_3 1 Tf -7.55696 1 Td (Updated version)Tj ET BT /T1_2 1 Tf 10 0 0 10 141 461.99994 Tm (\240 )Tj /T1_0 1 Tf 16.73097 1 Td ( )Tj 0 0 1 rg -15.11897 0 Td (10.1158/1078-0432.CCR-19-0916)Tj 0 g -1.612 0 Td (doi:)Tj T* (Access the most recent version of this article at:)Tj ET BT /T1_0 1 Tf 11 0 0 11 120.94202 428.99994 Tm (\240 )Tj /T1_3 1 Tf -3.50099 1 Td (Material)Tj -3.44499 1.00001 Td (Supplementary)Tj ET BT /T1_2 1 Tf 10 0 0 10 141 421.99991 Tm (\240 )Tj 0 0 1 rg /T1_0 1 Tf 0 2.00001 TD (http://clincancerres.aacrjournals.org/content/suppl/2019/07/12/1078-0432\.CCR-19-0916.DC1)Tj 0 g 0 1 TD (Access the most recent supplemental material at:)Tj ET BT /T1_2 1 Tf 10 0 0 10 30 401.99997 Tm (\240 )Tj T* (\240 )Tj ET BT /T1_2 1 Tf 10 0 0 10 30 381.99997 Tm (\240 )Tj T* (\240 )Tj ET BT /T1_2 1 Tf 10 0 0 10 30 361.99997 Tm (\240 )Tj T* (\240 )Tj ET 30 237 524 125 re 0 0 m S BT /T1_0 1 Tf 11 0 0 11 120.94202 329.99997 Tm (\240 )Tj /T1_3 1 Tf -5.66901 1 Td (E-mail alerts)Tj ET BT /T1_0 1 Tf 10 0 0 10 295.49963 342 Tm ( related to this article or journal.)Tj 0 0 1 rg -15.44996 0 Td (Sign up to receive free email-alerts)Tj ET BT 0 g /T1_0 1 Tf 11 0 0 11 120.94202 296.99994 Tm (\240 )Tj /T1_3 1 Tf -6.38997 1 Td (Subscriptions)Tj 0.556 1.00001 Td (Reprints and )Tj ET BT /T1_0 1 Tf 10 0 0 10 141 299.99994 Tm (\240 )Tj 13.46496 1 Td (.)Tj 0 0 1 rg -6.85098 0 Td (pubs@aacr.org)Tj 0 g -6.61398 0 Td (Department at)Tj 0 1.00001 TD (To order reprints of this article or to subscribe to the journal, contac\t the AACR Publications)Tj ET BT /T1_0 1 Tf 11 0 0 11 120.94202 274.99997 Tm (\240 )Tj /T1_3 1 Tf -5.66901 1 Td (Permissions)Tj ET BT /T1_0 1 Tf 10 0 0 10 141 236.99985 Tm (\240 )Tj 0 1 TD (Rightslink site. )Tj 0 1.00001 TD (\(CCC\))Tj 0 1 TD (Click on "Request Permissions" which will take you to the Copyright Clea\rance Center's)Tj 38.62892 1 Td (.)Tj 0 0 1 rg -38.62892 0 Td (http://clincancerres.aacrjournals.org/content/early/2019/08/07/1078-0432\.CCR-19-0916)Tj 0 g 0 1.00001 TD (To request permission to re-use all or part of this article, use this li\nk)Tj ET BT /T1_0 1 Tf 9 0 0 9 269.24255 1.99997 Tm (Research. )Tj -0.09303 1 Td (on August 9, 2019. \251 2019 American Association for Cancer)Tj 0 0 1 rg -13.61496 0 Td (clincancerres.aacrjournals.org )Tj 0 g -8.11398 0 Td (Downloaded from )Tj ET BT /T1_0 1 Tf 9 0 0 9 138.1792 769 Tm (Published OnlineFirst July 12, 2019; DOI: 10.1158/1078-0432.CCR-19-0916 \)Tj ET endstream endobj 213 0 obj <>/Filter/FlateDecode/Height 238/Length 73913/Name/X/Subtype/Image/Type/XObject/Width 1541>>stream H???Ϗ?????n`'??G6R0??"#A?K??H?"9????\?C|??\???9??-?5?= ?w#b?"`????ͼ?J13; uK???UoOu?{?^??E??+CD?.???K@Dd????GD?.???K@Dd????GD?.???K@Dd????GD?.???K@Dd????GD?.???K@Dd????GD?.???K@Dd????GD?.???K@Dd????GD?.???K@Dd???????i꺖?l?ƽ?eYڽ= !?Y?2?u]Q?E??I???e??UQ??:???h?\y?q??????]???&;?q?jm#?qb^նmUU?I-????V?m?i݃s?} է??I?iԮ{????[R?&?Lڝ??X??;??;A;???????lD?zo?g^ ?i?l?f??? 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