%PDF-1.7 %???? 2 0 obj <>stream x??|y|???9g??Lf??Y??I????lmY???d?j?T?*?,"????`A???P?? *⊠?WE??ET???9'I ?????????I&?̜9s???}?sR?B*Z?87}?̛?m?#/"??e??9??^?|'Bn?ī'μjz???p??2???UӮ????w? T? ???Iƌ?6??B??A&?{???c??7i??y??Sv???n??f?#?? ?? ?????7?y??a3 ?3gO???????~-B?6p?K~|???w?H?o_?? ;?n?q ??%.???ru? ? n/w???AB?R-,ꄻ?w???ӢO?K ?r<{J??췲?ώ?,?y~>????D?d$y???s7p?B???=??????`??P-?n??? ?D$?H??5??l}7-{WvS?Y??&?7?????N??h?"??n????????P?}W(??Y?M ́?[X??;g??????[??w6?;OnN??jsdz? ?????w+?k??7????w_@?un? ?S??j??\?.??C?2?e??}=??\?s??_y???r?wg?M3??6-?}?!?W?|??p)bM???R!(?g?~??cu/B????5????_?_ tb!B?x??8a;a??OXNh'?? ?xB8?? '?Ot?Б%l{+|??y ???\???UG?,@?????~b?wEG?B?????>F{?>?2? ???F??O?~4 ??N???4ME??4t5Z?f?Yh&???Aע9h.?G???zt#Z?棭? ???f1? ????U?L0?y,?s?<~???Q#j?"??????(~ ????'??U?a ~??Π??Z?4~?????????"~ ????ހ7?M?O????q=ތ?୸?؊?????&?a;:???؁w?Wp&v??U?~??o?7? ??z????»??p6??o???/t}???~?A???????????!ރ??!???8????????????ą?(?&։?????]?J?n??^?>?~q??????'?Bψ?????????k?'?'ŧĵ???3??~????N|^|A|Q|I|Y\/???Fq?X?O㧋??-?V?A?&nw?????????;?7?7ŷ?]???n??]?=?}??Cq????W?ǟ??&>.  D?^Q?YPU?ď?O???g?????/?/ů??A?k?xX<"~#~+~'???????ş????I??9?????4?dJ6?.eH)SrJ.?-y$?䓲??/????eh-S3?????[?;????vL?A;n??r???O?_???s??FK?%?#?D IyRXʗ ?RK?P?aͩ??E?b?f??Vi?t??TZ&?.?I˥?ҝ?]?J?n??^?>?~?9:,?B_HHJ???F{TzLz\Z#=!=)=%?E_???t?}-=-=#=+='????^?^?^?^??K1i??Q?$?K?5??Ѳ4??Ӳ?ͯ??????<-??kZ ??^???]?!??{ɽ?9r??|??O?/?ʃ???y??c?y????????? ?K?+??|P?Z>$?????????G???c??q?'????|R?E?U>%?S?M?&?K>-?.????????ϒe?v?l?9??`2?F?Ip??Sp?q)X!?[?(??+?"*?"+??*?b????????U1SA!W)6Ůd(%Sq*.ŭx?,ū??l%G?+%??*!]T?J?R??PZ*?JD)??Ji??Q?*?b?D)U?+??J'?L?,? ?%J?r??E?P?JW???]??Tzi?i?Rz+}tI?uEWuM?(}?˔~Je?2P? V?(C?a?pe?R?\?T?n??4????@c?1X???{꽌!?Pc?1?aT?UF?1?\`?d.4??͛?[?[?je?r?2J?Q?TF+??e?2N?LP&*W)????ie?2U??LW?Vf(3?Y?l?e?r?2??A?$w???nr???G?'?????A??9iN?Β_??+????[?-?n?????????Vs?BD?4??{?{?[?m?6s۸W?7?????=F?hc??K?)?c?3?K?k??{?G?$?+?O?O??9M~'g??O??P&t?^?^??k??Z?֤?-Ȩ ???9OI?s???8?7'-?"??\?"D??nB???6>1?????0?0?4?2???C?a????q???8f?`7~4~2o??n݃?Ƈ?a|??U?*R?JTN?UAUI?UEUUM???jU?Tm?]?P??(??Q???G?3????_?Y??q?1ڨ5?c?qj??T]?[??Y?W???j??WjP?UCj?V?????R-?>???/?????_?T?L?\?????%9N~$????h?H?ķq)ڌ?????h?G??_????r!? q???m|?S{?7z?c???????qí??Y_???a??6?q?????qOv?7?W4pd4I35??#?^?>??F_?2}?^k?k.1o3Ǜ+?r? V???M?4?W??pW<ߍ?????P??)z???????s??????|?@o????? ?D?2???_/?#z??ʸʘdL6?S?i?t?j???Fo??Ӈ?C?a?p}?^????}?>Hl.E????2?v??\.???#??m???^?^?^?^?vjo?wȻ?=?>??|H????^??|L>!??!r?!ߐo?w?(??#???_ z>L.???\? r??????`?A?`a??h???˄~Bah?.?ma7h???#`?k?9µ?3???,??k??? ?'n? ?#n?????? ?W|q7׊k͵??r??b??+??-?.?.?Y8)? `??=?r?)?S?i? ?'?? ?t??q??ʨZ˅6? ??q?Pl?i?%?3Vw?????h ?Q?z?m?v?&a`?V?????BK??q?q???x?x?Xm????W???rt?4v?? ??4y??iӯ?1s??k?\;??y??p??7-\???[n]r??e??-_qǝw????{???~=??c??y?ɧ?>?̳ϭ{??ŗ^^۰qS??-[?m??ʫ?????֮?w???{??ត??C????>????>t??L?ߙ??3ug????????;S?w???L?ߙ??3ug????????;S?w???L?ߙ????:a;??'Kxy?|?F(?|?????????h$?????Þx=j??=P?r???#'v??l ??Z?t??????݁?ǯE??a????xn&^????'????{7ވ4???8?'???E? jW??qߣlFQ??"(?(Āq5???x>?jy*??R>Tq?C#?ǽIP߃?p?yP?j??` ?ɫ?+lN???O!*B}?y??Gx'?Ը??Ѵ??Depfz??}??Af????O??C#???•???????{Ż!+??ݴ???f?G:W??9???g?rO?/????#q+?H>zb?7 ?tC?x?"??Hw2N???d*x??Yܫ|7x??o?Z.o?j???q????mh?a1??~???'{!6?F?b?f+?h?:????=?d?s=?e??????x??u/???"??u?%=lB??g???rA??s?\57Z??[ ???7|???bx???M?h?n?????? 5??eM??66?ǿA?0?Y? ~T??)0ޫq??~???0?? ?=3O???????????c???(??EU?.?????Ri?4D???q???\K?X???Y||???ft')?=???G???H%??ed?'y????4??.?(?ֵ?????[??? ??U?7k@o?͡???W,?s??Y3g\=}??)?']5q?ؚ??+G 4?k??˥?t.?Ա}iIq??mZ?*??lQ?? ???l?7??v93v?iXu??*?$ ??~h ?v?6?C?.. Բb??KF???+M??6??f???* ? b{z?x?*?????N2y?W2Y9? =ݓzb?6?3?k??=????=?}?ڪmP55?b?????3??zv?@??C?bY?=c?Pڂ?9f|l𐪞=??`u???>.46?B?bF?A??mbb???n?L?-l(?Y???Dck#???cFUŸ1???ܷG?u?Q??]??޽ji?Y/W??=9@w??bk?T???mu5?גp?ں^p?Љ???ndIuU /?[?ЧJ<߄POz?vJ ????&?M???ɪ????7feE?ŏ??????U?`????÷???^??x.>Ӫh?iKt???,z?0???Xq*??ܳ??(? ? @K?B?L??fB'T7???j W??ÈL?)?k????8?>&??P??w????#c?Gİ?;?"?I3??|J?E"??B ?;?)?? ?oߪhn ?f????C??o?Twn? ?^?Eca'?hHUb???z7?h?Hu???3;Sg2G?3?Rg?/????lofL?o~?3???1??_NOH??7,?o?Ȫ@Ϻ?d??~?^?|??sI)?ѽ??D?; ??\??TYb|?"??IT?#8?+f??Il??`??xQC???}]?,??X?????\?Q?,u4?k??#??ԋ??7??ģ?U?@???wC|g'???Ƣ?e?i?_?Pr???ޤ\???z???? z??֍i?/ ???m?M?f?̞?)?4ķ/??z??????;?* ?3uu?7 . ??z7`&t쾼:6(R??????? ?,:#Kpxmw??!????ˆ???f"X6?j#??{m??yp?j[L;J?Qz???ꇡk6???n?"????????#vLN?h\I37?g7??c9??O???J?pLN[?(?"YZ?3&=???A?d?o? ???????D?? =Bm?#ۡ?%m?+?w?9?n??6\?nc5M?\%?E?Ǡ?XZEp?ă???#FVmꂠ~????eZhD?1b?8?C??5ڀz????? A????Jl?)\䃚?c?Ʀ?z}?? ????j??rH??nL?m6܍ u?????ǻA?c? ?eo??P(q?҉?֍? x Ʋ鍓?]????-y??3?4|??T???&C?m #????B=?C ???+_MK???P???B8?5$??:??N?%Է.v?Ż??w{??(?? ??ga*?M?ƦUG?????\?ݙ*xgvqo????;?h?h"؛??Bp?28???Aj???4n \F{9y??Ց??N?@QP}?آ????@-p????L?)4?????? ?1u??ZD?????&?????xO?>m#?Cêb?[W Aý?0T????/xό??L???D??MH??\?;?6o?P???0?K?8P??t3????5?? [??.PV _\?珫?^ ??^6?c???З?UCE??J????;?6=??F _8??3"??2??9???"{?0+#?Np?><:??(?yB?/toP?W?O????}??Ԁ%.?#?)x????3ᨘ???+?б??!^?C?VO?QQj ??H??rH???ydQ8J?W (T?j??#?????????d?i???+ʗ ?#5 ?]???HĻ z???n??K0^????#?|?c4"?ov"e?&ڂ$ax?rx????.?!~??0?*D=??Y??X`k??P?H$?6{???3o?gM??&??t?^י?Kԣi"?ҤG?i??-=?\?:?yq)Y?-3޳ ???Iό???y?{?g????*M??eL˜??^O??j7K??U?{??????#??I]??idA?J???4?%???d?Fm??k?h0T?V?H1?tU?TA%~W+?+?V?C??BC_?E??F?@?Һ?3??1??⧐?*÷???v?F5?f6h-Z?+I:?i?J??Cg??Hj???V] ? g?;?:th_ z+J?Rg:h????+??C?>??ƛ??2??x??>Ͼ?䨜?^?Z>n?M???8??G?2?~??KUϿ?v٘v????1? H??3iVB?t|?>???D,??[?Tݰ9??23???? -??nq{0?L??)????oC9~O?B??? ?d???y?a?Z? m??R??ݾL?(CTq? ?6???2?*?֡??Z?*?c??E?D?(??_Y????O.(??k?4?6e? G}???u???W6???8?Žzi???O8#?????[?߹j??я??y?ΝM??+???Ma;R?N|y? K?l???+u1i@??%S??l[R???-bJP??MJ??da9%H)?,??e??IN BJS???v,ڱ?^e?dyȲ??E??????9;P???$?'?5???9??q??r[?[Y?????0 0{?G?????j/;?iT+)?r[?q|vv9???e?KT+?,\f??Yr}?ݪ?Y??ռ?E?[,?"r:i???R?Y??)???'l?-???J2C6Άɪ?[ɣ???]???~??r?????澿q*?z??3`W%?d?0bO ??h?SB?%9?v?QEO??6??Wuڍ?gUs23}vjd5??s|?#?.s??????JxT??1w?Q?+?33m?m????Wez??n?8?΁??>y???ìS?h?嗃?j??????M???׽?ܛ翮y???ׯO??1?B2?B̰U???m??gXN?????B-h?m?tl,??mE?E?a?[Y9?Ձc̜<݄?S*ɥ?5??]??b֣??,<)BM?ϯ?n?#?q????i?L??]/?׿ݪM????;g?wFCW8/M?9?g]?!kAΊ??99?e?????X?L ?R?cΗ?\??E?"g?u4?M? ??8??zz[ׂ4????O!?ʸ ii????rZZ9 ??d?????fХ??SZN????Ri????$?k??)??s?L? ?w??G6b _??5? ?fM???4?ӣ?f?'? i_Z@???m???A>f??tP??|?9̰?;?;?o9???w???>??W䃧??۸n??'?0??/?b??]9?_??CM?5???CӦ?_?J޲?o??6??n??Y?p ˿?%???????????o???d???L5?u? x???$?g?*1!??8[?????Yj?!?gTe鍚?KF??S5?̳K??\_Yj?????W?EY?y?=?,7kh91??pf89?˹??n??[??S?Q?f? ?o1??n@&?Y???? Ƥ9?Tb ??.'?#??P8X? \?$ \???3Q?v?l?m????SZP?b????A?DdE?"Y!?&???L????ZJ3u“??gj\??_???̊?;?}?vҐ-nu{Q*_?4?)?-Ƕ?|8k???"?Td??Ĕ?3??[l??h?˳??'?_??{8qeQ??N?Ӆ?ԷD%??????eE}?>E?rud?<92ײ????"???V̛m?J]?A?{t?-IK_k??.??ָUxܺ??+?&;?g??Zie?!V??P??F8h6??<*?H=.k~?ɭn?͕?pp?> ?#p??HU??p????$??,?g?Z?㴖c?1LM:?l6;(~>?rk?Hd??5?f????p4??d?GY?6?z???A8?h??X??(u???5?+?ւ(?`????????ZɈ???? a?????*?ە1G1????edM.sѨ?V?S:? ?sۤ%mR?O??郸?M???^??? ???T??ќkI?ӺR???Yh$??É?d"?-?J?@d^?خSsޞ???x????ٖ??S'?q?|?=u:?F???D?&???ς}?P$so??? 4*E??[?X,֖\???V? T??ɜ?v?|?D?MjηUP???E?4?K?????4?K_?i%B?.???\?L?\?|N??$?jA!?|??)?_?}M??S?? ??\??????}?/{~???r_???1?x??IO?g?2?? K.??Yya??V?V?r?Z?/:???N?[ri'?u ??b@?>?W ??:??z??e;???`1??BOA????????????f?W?????rp??g??5z?Q?2k?Q?j?Ϫ?A.???4ܝr¢???}6??V?-????1???I ~??L ?b????*5S??#T@??m$ B[?[*m%Ȟ???)? ??#?3{Y¥?%s??J.L?N?W?58?Oaޏ+? ?A??Ĕ???l?^???$?Stc?nL?1U+V?I??ݴ??A?=9?;?9??騟]>?lL&???/V?xx??X??NB̚??Ǫi?L /zY? JQS)W$?Jl??L?r 8??B??[=[?{?????M????TR:??/>}???퍿?5???i????G??G,?????{???Ν??E?$???T?WMei??`?3%?!Js???օ6(}F3!???>Mr?x[3%?????Zb?dҾ?????t7?@MA?ś??}?3???e s?fԺ&s?k͵YY??S?dn?p?e??HƲY٢n?X??}G8k?hc???? f ???F?B?V?5?:?d??F4?M??`n4?ܨ4?2?7?^????i???b(O??1FXG??G8??3?&{wH?p1?E??0he1h??e??;3??$y+3??J?/UHD?? $?V 1?,?R??%?>R;o???$? L]3;????Z;U??٧i?;;???4k?›???Y???*F??λbyM?3?դ氶$9Ɂ]?UB???TWSVlg?? ?s?M?????l?tE!T9Ȣg=5??S'???N+U Kc:ֳ???)?_J??R?ӏ??)?xK????\H??);m?IѼ??^R0K?T4RIC?f????c?a?g ??MmMd@#??M?әY?؀? ?H???g?'?R??#ԉ??f#f??5?&??h霨?bL?f"??I28S?3???z??Iz??????M?VҦfVř???R??q?%?E???E?l???W?8?????ՍKƭh?? ?t??}?:\?z???G??M???2?O????}?34??0\$?G.|%?_?C??????'??y??N???z̳??{? ????ٲ?Y ??3Iđ?s"Rw`G<#1X[+3??+5p?!??91B q?L????ԮS)[??KW"?R ?Du? ?`?,7?KI %?f?%RA????`? ǘ'Hkl?=?????? :?U?DΤs?OC4ψ?d?d?q>[RFWu?BC??H? Q??ؽ?&^???ŋq(d?w3R??h?~'?FW ?ZR???C?Kڗv?? `???ʤ??<#떹?Gy;??w/?ЊYSK{]nT?U;v????'?5?~???-?8?j??(?Ž?ZO??d{???|GQ?L??L?娔??I?Y??Lk?PQA?P???+??I?ZV??z{??r?4.8?emѢ?? ? ?Z`s9??????/Cb??@m????B]? j >?????YTgfI????I_??[?ʝ??R^?v????銺j]?\|?"QĬ??Y!W?r1+D??џV???sGI+?Jd?@?y6???&?i?t?1p??S????O?U??{??k6??7*?A??h?HZ?֕?#???ȥ?2|?E??_?Y&?)???)2????L???'f?㜡?G??G+ʓ?g?7J???? ̓???U ??bfF ???4??G??\4W??̂DΟ?-W?????H3^?k???,X?⹱?????Wnxf5??????{?y?Ue ??1??? ?+\t~ʟ{??~??????哥q?w??^b}??;?UJW?DYd??s=??:?e??dg?!"?? Gf??N??gE?? ??U?i??DPX?? ??V)l-^???`????]??ݢ?H?`???? ???u???̴?l .b?mi?M;?ܯ?ک??(?p?{j?>?8???K??7?p\(?'fR?B?b(?c??˜?{Xv????6l?Y??f1:?!`q??-?`??)Ll?E????[b?9=fo?5?ܩ ˝2]?d2T?t?Wz?????|'/???N??蝼?dyY??6%???B??M?Gx?V[) ?nJ??P??rT??x?4?F???A?Kh??Ef??+L?IKy>??:??L??9ȓn??6{_?%???JK??$??^?o?sB?c?f#???ml?xYʠZ??͋?zfʠ?"??J?Q?T?迼?L0?[?i?‰9 n?&&?b?*Rz???زpf?Y?n??(~f???7????B??̼??j|?ŝ????[?}?????ѝ?_???8o????n?2??v?c,??81?K?3???J&??d??L??(5? j??@7??,곹O??L?w̽?ͻ9R??LaϙB?3?9C???ْ?2???????fKs??$??????b?~????i?]t"?X!)??*N^?ߜ?MQeUR9?̷?V/6T{vt??,?? dPt? ??;?????ᔜ?J???'???????Z_8??5?????9s@??k?mWO?zχ???????Zt??q??-?lm}??ee? T?vI?Xz?}?J?Z?J?,˥fg{gg{wO??????{?0Jj??k?C?Ӆ??xs?}?s??:????~7\?^a??M&??|?d?t\k:?2???XӬt?yY\?ep??X$??fr? 5????T&$?f?Z?¥m?1?L) qR??)M??dk?i* dk d????D{W?d??l?????@>*??J?#o?K?(ܚ?"A?D???Y??U?.?????AKG?9+Rs&RSs1?R?K?)P??[& S? c?T?? ??-? ?xW??gRڏ?:&?۲?Tz(?c??o??O,??tr?ƥ?mܴd?F?? ???M?7??????????HK?&?A@???? ͱ???K?~&_??????.?,??=3?2 wvu?^??[-_a??"O?L6???zw?;?v?????hΑ@:-):}VY=ʓ(O3?|???}*6ըZ?.R??U ?\?,?Qp???~bYW?R???J??`?v???Rr!anm^Ğ???J{??<㘚h4?&͋&???D#[\??M4?{wt?f?'#????9F6?h+?x?YmV'KGX5?????j?b,??XI?0g???7,?qi?Y???=???r??G??????y/<;?M??W? Y?s??wn<ǭݳ??>x???K"?56?~??M6y?K???0~"????Ȋ?aSt??XcÍT??J˹? ?Ar??w? 4?$??G??>??Q[?i?_?$??R,9??{??O??Q?????ϴ??R??@?{K?leQ?l\??J????C????)$?????'?L????.ݺ]r?#??bV?????????)??????ö|?????ޠ????HS??%??-(? ?ɡ497M?Ɂf7a~%?????\??ȫ̝?;_?S?5???tŕ?v??W??K????Xu??G)??Q?(?(}?b???E??]????_?nF/^?????fj.???a????g?N?????????f>SJ?9????KX?_К?/??1A???4???! o ?b?q????߻{???? ???Ց?????8?m????@??? ?~?/?M?=?ǥ!w???⁽?o????*??QC;?|?j^I???F>~???Vy??H?????,?(???d9M??d1MVA}B?? ?\?<a??b9M%b??p?a?\???????????w?M?}??@HXD?\"?M6?Ql?(??X?Z?"? ?-??l*?Y0?` ?*B?R?B[\Jw-~??????9sn.0j?=??|?~睙3sf??;?23?"?BA???w???r????n???:\Y?c????>?AcWl??nB ꛢ????)~?P?~?Y????\?zE???7o`?{?/??1j(?^??????oܘZV?z????W-S???x?4͟??Ƞ?9?gfB??ߗU6?{9????U-H??_?GҺ??*???%5# j:???ʌ??ʌ8-#ί?(??d0Gx??¯̌?ͣ?1?L??3cef??F?+??b?"?=?d?r+Sٙ?d?a?`g2?????%9?r??O ?Lp?"`[?yg"f8??P????t?c8?b??ܔ????Z? >?M??¿op?IKyru?T??6"?Y?^?? ?L??_?WM????z ????\bDZC?;a?1[l?i??ł???a 6?r??'J??a?v??9?U?~??'???6$??6??s7???}???aZ??Ž?????Pa????vr??/#?????j=?"??W?|??t?R\?%?+,?J? v(zGi??T?K0ОJ}?????ߏ??G)??1?K|? ?D?D?-t?r?z?????9?u?v?g??^?T?{ȿ???K?=???Ћ?Ct??)???A???:?,??R???E?>#??j???:?8???W'v:?A?u1 }?}?i? ?^??a????[e?`_پ2*??\????x?E>???'MUa?) ?9????bz?>??T%??????Տ??+?6??˚????d?c-x?UV?2???V*?o????HQ~V٧[??Ջ?zڈ?Թ?+M"c3?2b|?<8+Ƒ??.n??f?@@~???!??!5Ɵ?I? 19߾?fl???a????|?9G$.??9k?y'?"?y??????/n?$??=T????J??9??9??Y??Zǜ7 ???0n??C??ǹ*ě?Ȭo?m???Χ>> ??}4ޔ^???G(t?yI ?;7???];?? GE?? ?R? ?59`???U??a?\8??p????:?/???꧊'?8)o?eӔz{?: |i???.??ޗ??N ̊͗ߦk(?U [?G7?몛_???ˎ:?f?/)? Q??????&?JiGE?޲????s??ܔ>Z_3???tA?ox@???őɞZ?Ց[??<7z??ۂ?"_?'|?I?R*M.I)?D??Φ??????گ?(+?I?i??-?e???7߇???"??o|yI&?8 ?!???6??:?+????????-??Rxq"ţ%+???-??hVcɐ? D???j????????b??????{???_???????/????????_?tƿ?h?f?e???{?(?1p?A8??????]a????D? O?axR0?E?)i??)?p0X????81IF????`8??,????z<,?"? ? L?*??\???5p?3Q??2??ï???#??!aeZxFXs,)d(W?@??W?_MNE??c?]???X^??~L?9?ٿE#?bX\? ??'p圔?<)?^ 3???|i?!? P?>o?Cy???,?8O??K??:???$???9OgE??>p]e?gK^??s??f??ީ?&?? .*????????4???6??X?????????????O`9?S?b??)ғ:?ϥ?Pc?U?2??5?I???Ι??z?!5?UD[?DS6m߶?J?\?uq??6?mڰ}e??@],<ޫ^?X??}????7~?*[?m??i????Q_?'???y??)kg?? ?.~?R|?8w??@ ???|????Σb?M?x???-?%iy????d?F#???h? (|?`vyY?[9Y?r?CL?ғw??yJ????y=K?F???hr4? J;w???E2??"%I%???????R'?FJS?e???I?>121ub???Mɷ?oK?-}V??y?y?????W$=?ޖ?????/?C?Ӭ?֑Ԭ???R?d?&????>???Z0;??YDJ ?&?` ???$;-5?(?OC$?T.J?%%?S?Ӳ$?@y?!X&???m?/0GL??????zy1gS0????v(x?Q?C?lcʜ?f???GOa??)Є?{? ??ׁc?' XJ? '?+??Ͷ?U??i?v??/3\l$5M}᭲???w74M?ݮ????6]?2T?.wr??^??????&u??V?n?7???.yh|?ח?\????e?t`??'?m?fm??!?Cԇ????m??M??}????B??????o?$??$֩??????????Qt?2?ƪ??v?֊???yW!?t?E???߁^?( G?~ ?8?n?x?u?A??Xo>M3FY??o???&?^??K+̞4?Pn?Nԃ??s?#?qܿi?@/A|)??P?? ????m?Ru?T??y?r??h????t?s??~٦Sa?q`??0??s>?????l?Z????e?d?` P?? ?j?_?3̛????n?!?&x?~?Eb??ic???m??<_?gі?g?b?q???ɂ?????<??{?'ԗ? ? xˡ`?M??:???O??i?K=H3?|?????$?s?C~uS?????AM̿W$?H|| >??f???Y??h`???I1??CO????O'??3??K7??ݙ?????Y>??c?r?匓?M??߫???Gc?.??6?#?>?0?{?e?5?3?k??V??0?g???t?%V?ԧ?]j?S??G?J?*??SB?|A?zt?h??\K3?w?@??%r?????????h?#[????t`?? ?,? ??_??Yͧ????l%??????h???ʔӌѴ???*????;??NJ߃??c??%{?!'P}%????>??3?/??d"? ϕ??F~?RQ&J?O???a?0s_??f:],?Oh?1?Fc-???Rs$?\:??3?F??????Wt)??\Ȧ??9$??uB[???r???G?)˨CN??G?e????**f19??į?^??.4'?|??7 'Q?}H?? s??ϗr?P?=H?Ul˰?????T?N?$??v ??>???? >????a?u??????Z#?%???W????ZI???$?Y?n?契?(?к`??,?Ϙ??i????^Z?o?y?S?T[???ے?_??????x=??{??\?VOӵ??{??_???F9?~?I;??ϕPޥ??(̭??D>Q???C?Gg?rqmu?j?:o5c??r??????v:m?|?^<5????R?1nx??Ը9?Jj;?5??`??????哩/??.C????F2????s?j?????q??=>h_??Zz?p?????y?Nsd????F?3=??'`??v/?߮K!?*?7a?T??<??R?Ƨ???r`9??п ڻ?=??piW?>At?K?o@?????iWf#m?,??n???2?7ǀ?v???I????[???G??Q?n?????? x?O?\??????T ?? l??????????Ka?\?v????n?{Sg<[?n_???hܚ???????}??}???q??l??>?j?M`;?mY????(??߄?z??ʶ3ۯl;?? ?T??=#???z#^?*?hr%?????r?\ <Luƚ}H?}X??e?Wk}???l?i7?x? ?A??43 ??gx=??|ּ?g5???<????r?Z??}YkzM??>?L??|g??t^??z??E??]a~=8??Ǻ??{B?u^???~?%Q????%???+???:F?:򻰍?Q?J???F?????ث?????`z^?o??E?ݴ?[K5?b?i??8?D????q?L쯌t?*??Ӭ??ZfNlMS???&?G?zL|?N9ot?b?^?l????????+??N??i?I?{^#u?M1??^?Gô;??9k??A???l@???-N]??3?B?m??h??g???Tj?>\????x??13?1?????L???????v v???|???|?5????#Ћ@?}M?ul`???U??5??zT?&?Z2?bx??jkX3?????k?N=?#@`?]?m?n?- ?lZo?o|?eW<x߮O?Ͳwh[?1?~se???7=Ҝ?)?~GQn]3,???A?7?i?k?o^?-???ֲ???7??}???qtu?g?M???EB?z???N??wi??wd_/?0?a?#?@Ro=]???UT??Oy?9????P?Y???޽?Ґ??^_?|[\$ڌ????[?9????'??=?Ş?J?ᣓq????z|???i?/???_?=Lةeb_~???μ?乚?s?????#???w(??9??ݖ??{1"???z@?:????:??g%?v?cG?l ?F[sp???g??%??7?5???Oө???Ě???6?}???%i?zv????&??i?1??J?=?(??KYl?y<®??:?8[t8cl.?SX??}1k?????`&??2??*0?V?Gʲ?o???3D???W?/????p?Ʒd?g??j?nC?!?v???????n????w?T؆L???I?5????}~?L?Y?Î??CO>????%-???i?Ɵ?i??%?)?w?N???8?4??5?fj????S1&?I;???b????|bg????Q >Op:??$ ϔ?!??3?|?o?ֿh?6???H,ch |i@??_??_??|?޳lx????w}@hRoDP?u?wV?sT?>??p???G?_?n?㽯??٩_>????t\?[??]m???g?????giVQ???~???J|S????7? ?Γe?>?c?Ɯ?x|p?z_?B??J͡?ck???K|?X?%>`??};0/?tߋ?cH|~á?j??a??H???Yz????)?O?sMع?>4??'?}O???`?b???9?R?ij?'??Մ޲x> ?l???2?3m?[?ds????hK??MJ?e?Km?????_?f?x???????-յu?????f?tV???Sq??h?,G?qמKK?e?U??k?Wv????o?|}???e??Q?^?GK?ܾ>hj'?Dy??5?Wk}?Xӟm??R!????y?[???XO?9?K?,?D??????@?ߊ?&b?]i$?Z??Bg??n?i?7?,[?=T?~k? ??,??hc??"?v?2??|j%??Z??#dR?-?4?????< xd,????'/?~_??^/?I?m?Ǩ?,?أ/8?űg??t?(??pO?!???y-?m?-xk??????c47!?!ԑ?Qv"d?e???|????Ȱ???????ǟێg?v?aK?c?^d??Y???vؕ?##????\+?*???zȃ??﵀L??߆?:?2δP??? ???_ ???[?*?iz??&>???N}Z?=-=?e˧?=??#??u?,c?H?ɵx,??q?/???B?? 3 6??e?K??b??bԏXz??&??b?`?????X????߁x+?o(b?S?9???9???3?ΰ??ΣdO*e?R?g_?{??'aMk???[b?? i?V???r#l?1?+ ?/?C?߄? #j?ZM??x???V?m3???#?vH?????>????¸0??k%???)M??:?7???1??O?6??׈??/???HO?{??zOz?s=?^?]??XN??r??BӇ2??!c????(????昣??C?o%낼4??֙??d????Y4???m??3???.?I?A?ԺUy?Z??S?r?ڠ?Q????]9Gv?JЩ???O; ?tc???0|?9泈?F|?}?J??B?#~????>??????/QH?і??3E??.s???z?F_?񫭯???>??;ns?ZO?^??0??T?=@w ?iR:?M?D??]NTr??=ޣ#ާS/??S?Qau{????9?%?Uo?%???F?Ꝥu?j!??|?L???Z??U??t}qV????tP??e??j%Z??s?[???#???gi??\\ p??v:??Z#=?? ?X ??&?|??,?????P??]?e?l6^ ?e?Q?4?3?f?`N??v??;Q-???J?=??>A?O?R!?????.?????t?0???og;??֥??ܩڦ%m)??c?O???;C??Kf???᪨???P>-??i?j?L?j???+??tR4US??򭝚Ґ???W-?(E(_????}G?l}J?bq??;??h?;???4C=?}?k??? L?0???Vߦ???U?x`1?8 xԷp?o2+?+??U}א?^?\??!???д?i?ѳb????@~? d??@$?b??Z????b?48j?VH?S?V?P????kb????e?KzwV_?u??????_?`(pp`"t??T<,??2\C@???p?:Q`(?U?7??-?????3?W?ݔ?ߧ?,?ԗ?????{@[??U_jh?O??p?P&ĿZZ???????"?Vﰺ}??k9P ???C-l?͏?!?i?????>t9-?RtR~??0`_??9!\,.V?? E?/????_?_?o?!?O? !??NB?/?c?#ė?!#?e??hs???C&+????襛?K7??n&]????q?۶??C??cѲ???)u?+u+u˔????;??;??^J??J]?R??ԵV?J?v?ltE??pR?g4K?۫?=??MWꊕ?"???RW??nQ?4???BA???Iz???>A?z?x?d?\_,?"SA??9?5?????x?s*?a??B?]?]?w@????Cv?A\????N?(`&r???k?r? ???h?Q@?i??kEø???C]݅????Fmm? ???i?)??ʐ?Vk?edQ$?oQ?7?;??'???O?_}?E????4??V?????NW~M?up?ғ??"гi??w??u1?A?e>?`?U??????~??d??#?R&_*?юO}83.???:? ?Y?1|?yDV???~D??>G?6\?5o???PxR-??d?ѣB???[? ɕHw?%?4+iF?JSrZN??%yL??QyDd$O??SCGp?FS̰??b4??)???㰯?,???":?S5?C߶???ҿ?Z????G??i?ANͤwu'????;T?,z?????f??h??mg?-?9T*?7?Z??n????-??,5(6.p7???Yj?57hm?hmm??˕???????+??`?,W?p????e???rX??Q?_?7???7"{($?`?6???9?????pq6??=?W?W(?{??f?q8?kama??`k1?ȗcWf?8?=ƯbW ?I?Dz??wQ??Š~>?:]6?Q???U?gSc??;9?fա??n I?6ِ轁?L?a?m$~ ?=&??d?}?%1???ߍ?:??›Cl?p??HsNM??Z?ڨ???bŞ?????A???uE爍ypt?q+??Nl????Lɰ??҇3??a?t?wmB?#.?5xw?v??%?K⢑?'?P ?@?c?F-2????=??? endstream endobj 3 0 obj <> endobj 1 0 obj <> endobj 4 0 obj <>stream application/pdf Evaluation of machine learning models on protein level inference from prioritized RNA features Xu WenjianHe HaochenGuo ZhengguangLi Wei AcademicSubjects/SCI01060, DOI: 10.1093/bib/bbac091, Briefings in Bioinformatics, 00, 00, 3 11 2022. Abstract: The parallel measurement of transcriptome and proteome revealed unmatched profiles. Since proteomic analysis is more expensive and challenging than transcriptomic analysis, the question of how to use messenger RNA (mRNA) expression data to predict protein level is extremely important. Here, we comprehensively evaluated 13 machine learning models on inferring protein expression levels using RNA expression profile. A total of 20 proteogenomic datasets from three mainstream proteomic platforms with >2500 samples of 13 human tissues were collected for model evaluation. Our results highlighted that the appropriate feature selection methods combined with classical machine learning models could achieve excellent predictive performance. The voting ensemble model outperformed other candidate models across datasets. Adding the mRNA proxy model to the regression model further improved the prediction performance. The dataset and gene characteristics could affect the prediction performance. Finally, we applied the model to the brain transcriptome of cerebral cortex regions to infer the protein profile for better understanding the functional characteristics of the brain regions. This benchmarking work not only provides useful hints on the inherent correlation between transcriptome and proteome, but also has practical value of the transcriptome-based prediction of protein expression levels. proteogenomicsfeature selectionpredictiontranscription © The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com True endstream endobj 5 0 obj <>stream x?+??| endstream endobj 6 0 obj <>stream x?5?=?0????u?} ????@???-_5@A?5???p?<(?m?x?Ɔ?5g/ [?" ??$?rd2?yݳ?!>stream x?+??| endstream endobj 8 0 obj <>stream x?5?=?0????u?} ????@???-_5@A?5???p?<(?m?x?Ɔ?5g?a ]3B$!AP??S?L?<Ϡ{?:???SV%?1?h??z? aܲ???0_? ??? S>??Ȍ?w]%???$.)O????Q.E??JI?????}B?Nft-b?㵾???׋?Q?b?>?7? endstream endobj 9 0 obj <>stream x?+??| endstream endobj 10 0 obj <>stream x?5?=?0????u?} ????`???-?ł???1O????f???'?l??8y?b?0B"!AP??S?B?,?;?؅g??+41t8O?0n?0n?:?x?܅NXo???wub??ݵU?B?Tf??Z㨔?PJ?`_h??8!???)??R_?LJ???d??q?dk7? endstream endobj 11 0 obj <>stream x?+??| endstream endobj 12 0 obj <>stream x?5?=?0????u?} ????`???-?ł???1O????f???'?l??8y?a?0B"!AP??S?B?,?;?؅g??+41t8O?0n?0n?:?x?܅NXo???wub??ݵU?B?Tf??Z㨔?PJ?`_h??8!???)??R_?LJ???d??q?e7? endstream endobj 13 0 obj <>stream x?+??| endstream endobj 14 0 obj <>stream x?5?=?0????u?} ????@???-_5@A?5???p?<(?m?x?Ɔ?5g/Sl?kF?$$j?pʑɔ?t?V???`ʪD=??4]?;!?[??;?+w??[aʇ\?q?D???%?????8ʥȔR))????O?Ɍ?ELq????!?z19jV,?e?7? endstream endobj 15 0 obj <>stream x?+??| endstream endobj 16 0 obj <>stream x?5???0??>ō:????htt0?????Z@?ۋ??n?[>?}?x?bö???/P@?a%!AP?S?\f?̡;?؅g??+?c?Ў?m?aܼu??0ݸ ??? S=L?ꕉ?w?ZT? I\R?~k??R?\)???}???aD?&? %?R_?LJ???d??q?@Y7? endstream endobj 17 0 obj <>stream x?+??| endstream endobj 18 0 obj <>stream x?5?=?0????u?} ????@???-_5@A?5???p?<(?m?x?Ɔ?5g/???!?? ?M?)G&S?g?=[?s?)??z??t??0n?z?x??܅^Xo?)fpUd?ɻ?e?B??'??Z?(?"SJ??`_h??>! H'3?1??Z_?LJ????Y??;{7? endstream endobj 19 0 obj <>stream x?+??| endstream endobj 20 0 obj <>stream x?5?=?0????u?} ????@???-_5@A?5???p?<(?m?x?Ɔ?5g?` ]3B$!AP??S?L?<Ϡ{?:???SV%?1?h??z? aܲ???0_? ??? S>??Ȍ?w]%???$.)O????Q.E??JI?????}B?Nft-b?㵾???׋?Q?b?>stream x?+??| endstream endobj 22 0 obj <>stream x?5?=?0????u?} ????@???-_5@A?5???p?<(?m?x?Ɔ?5g????!?? ?M?)G&S?g?=[?s?)??z??t??0n?z?x??܅^Xo?)fpUd?ɻ?e?B??'??Z?(?"SJ??`_h??>! H'3?1??Z_?LJ????Y??>C7? endstream endobj 23 0 obj <>stream x?+??| endstream endobj 24 0 obj <>stream x?5?=?0????u?} ????@???-_5@A?5???p?<(?m?x?Ɔ?5gc ]3B$!AP??S?L?<Ϡ{?:???SV%?1?h??z? aܲ???0_? ??? S>??Ȍ?w]%???$.)O????Q.E??JI?????}B?Nft-b?㵾???׋?Q?b?<-7? endstream endobj 25 0 obj <>stream x?+??| endstream endobj 26 0 obj <>stream x?5?=?0????u?} ????@???-_5@A?5???p?<(?m?x?Ɔ?5g/%??5#D?I8??d?? ?g?Cx]0eU?C?v?????-[??? ?0?? ???8y?U? ^H????[k?RdJ??? ?\?'? ?dF?"?8^? ??~??5+?c?7? endstream endobj 27 0 obj <>stream x?+??| endstream endobj 28 0 obj <>stream x?5?=?0????u?} ????@???-_5@A?5???p?<(?m?x?Ɔ?5g???f?HB??6 ??Ly?A?luϡ ??J?c??N???¸e??a?rza??|??U?'?J?? I\R?|k??\?L)???}?????0 !???Z??k}a¯??f????7? endstream endobj 29 0 obj <>stream x?+??| endstream endobj 30 0 obj <>stream x?5?=?0????u?} ????@???-_5@A?5???p?<(?m?x?Ɔ?5gO?B׌IH?&?#?)?3螭?9t??U?z =?i??wB?l?w>stream x?+??| endstream endobj 32 0 obj <>stream x?5?=?0????u?} ????@???-_5@A?5???p?<(?m?x?Ɔ?5g?b ]3B$!AP??S?L?<Ϡ{?:???SV%?1?h??z? aܲ???0_? ??? S>??Ȍ?w]%???$.)O????Q.E??JI?????}B?Nft-b?㵾???׋?Q?b?=?7? endstream endobj 33 0 obj <>stream x?+??| endstream endobj 34 0 obj <>stream x?5???0??>ō:???????@???-5@A?ۋ??n?[>?6C>/Font<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]>>/Type/Page/StructParents 10/BleedBox[0 0 595.26 782.337]>> endobj 36 0 obj <>stream hޜ[m??8??޿???C?)???y??K2=?={7H?l??5?%?%O&??????HJ?^Jv/??$JzH?????/y????^_????ׯ.??8??}??????}??:}ȋ????=??]>T/?.???????B-????1??8?/U?,????]????n??]|q??ś??7??z??E?L43?*???S񞿍ǣ??7?e?G??{x?6?o??P޺{mb?Ч ?W\%A?].~????#Z?w???0?dK???o?,??p??Wh?\?????w??.cx&?0?p1y?ޙ?݅㥐 η????_?{쪝f扁ML^??ȗ󥖱?f?~?]??R?R?ŕ?i?p????*J40Ӑ? ?wƽ???k??JK?????? ?;;??g ƃo(i??F?0?3??l?uV>dE???xK?C??N????u?lc??^^4P?c^?V??,?~????y3¼.aV`:??s"fr??O[??????u+?hb??Z?P,??(:T?Ȋ???/???ɡ*Ď??1?WG??c\?,eȨa?-?p?.? ҢZ?}]?+?Gxy ?Q?V????Q?????'ޝ?1?k`a?\??1?U??o)Ual??D?q?p䌅hv???2! ЄP?iU >??]?E4ld?/???9i`FFE??I|?QaфQn?%???K)?%???7?OW?? G?ĩؽ?6`?i?"??ד??~????,2?C?-?m?/?? ?}^|?P&?L$??1?9???'&?k???E?+??o8-?|YLai??MN1H?h?&?? ?W??yH?????ܖ??j0??D????*0?)pZ$???b??&?3??MiR?Ϊ:/(^sNZ?ia'?B?H??!?|?&-?H?C C?4??F8΂???ӌ?ЌK?f?)?qEӬC?h??Mh??Ù??4?:?>???4?X?d?4?? Ҽ?ݧ%???$????t[?.?"}?!?jaB 3?@>??/?'?u?3Ḧfؤ???? ? ŐH?,{?h$?5?!Β??\ߜ˵H?\?Oq-Jh?u(?(?i?k?pf??4?:?>?(?nj?????H?s?^???w?WVuZgև?+?HR???$C7?P?1ͫI?J*f?ͫi?}Isj??/cE?)!?????7????ύ?&V??)bŚ&V??+!?Y?4????K0?X?y??&??&/?>?p}M?E4?:0?W Ȟ?}Z??l?=n?C??k \???u^??R? 1ɱ)1??? \?0?L???J ʹ=???????Q????Y?'$?8????Ƚ??\O%4M???dH?C?E?a?ф?3C(?iBu=BqʦɈ&??4?dLj j??c?Ь??;')H? ?????i2):EERф?A?f2? ?S?P?պYa?2j*?w????@p?2jh? ?? ??c??zgޓ?\pT???p?4?iءt4?f?QP??e????\?????iZ??y??S????d?$??V???oO???"y;%??9BB?jˆdY??!? ?/????1?4?dm,4?M^!???%?B???t?z$E?^t?Z?p)?-??? #?LE??!?L5?C?vk?VBs?=?Z3?i?Lf???`O&?L?????)6?.GfbH??I?L??Oč?.N{?t???uv8V?@???t?6??????????>?^??Z???????5S??O?3%hf?`??,G;??c;I????Pj? 6S??=?`3U??lǨ?ҳx?Q3?gf?Q5??:?c???????F?v?Q3??!??ez6S???I????c???L?yZz ?f*?T?i??%?3Ț??¥??1?9??T?=???|?R?3?N?i??????$f??C???!-?L?y?d?4S???^?SQP?~Lw屲Q`dW?.|?e???U4O'?? z????O'J?-O=)?_{??Db?'|?O??ſ?O?%?F???4N?"̴%?Є?*??I'?^??DϡqBo?=?? ?y???7??f?nv?? ?m} 9?&?ƑA???3?>??On??q???H???qr?$???7????0??L?2?W?W?4???C????w?x??4A??F???????>?L?iz#??????N?!???m?r?M??5`r?? ?5M?$?)??xH?%?Տ?)yH?%?ȅ>Q#w;+c?+V9?x?ݍ??$???"Y6?0?8??͗?v??H?q??|?'o3?sf???D?????N1???·?k????`?)????kS?r>???W?8]'~N???Ƨ??(?g*??]i3I_?,K???~?H*+??????bU?`??c?j?q?k ?Lj?!???IWӽ?O?q????LǮ?\?zol'?8SO?K?:ΔӇ`O??L5}8??_????-??.?{]xv?vq??;?I?ӧ?h#?I?͔?}?i?1??:{t'97Sh???ۯ?g*?#?'?n??>??g?Mn?X??z?rt?}4x??bDl??T?H???vB? ??3?vk???? ?8??}?????>{~?>?$?ea?~w ?-#8jv?ޙ?݅?R???????' c??6L!?1B??$?&?????T?o????2??(a???˘B?A??!?1?@$?#?4>????C??1?~??G???TJ??2o?E?K??? ????h?@?|8?O??K??( ???y?3?疛^P?3?W д?iH?s?V?U??W??,??(?=I??:?@칡=:U8. 28? ݮ??=Zչ+???p????6?B?d???c?eK?ɋ???lm?ö\??L????H?j$)5??H E??d7l???C?dO9~@????p??v7{?vzW???A?#كk?r???}n??|^? ?i??XYyb??p???8?YZ?m????6Cۇ?ǖoy?h?v?w?f?j?7R8??Ss?7?TŒ????X7|?? ?GЈCe/?ˣ?I?|?yİo?>[ ??`?UVÏ??ǴhJW??Ue[`~;^?A#???~?w{4??? ??????je!????0!?99?b???{&c?c???? ?I?Pm?p????񢓈d715*??'???? U??????}?Νe^??I`????u?1????֨??K/?V?ht???0?.o?d?K~#?$?*swL? -?Q\޼?v????պ?[?u?Ar??;&?j???*????b???k??????{x ?? 2?1?S??^!?ֶ????,+?=+9t??S???J??$*6?R???N?? ??g?????a?]km???[?*?ɱMp?{괧v????C1^d??x??Ȭ?$J폢??x?2? 쎇??p??&???S?}????@g?tN.P??keʴx????l??k??H??6)?!?k?O?y????????|?A????מ#?c???K?x? ??*GJ4???Y8?L?ϭ?n?˘hf??L????M? ????6_?9)???h??ZҨrc?b???????J??o?Rl??? >/Font<>/ProcSet[/PDF/Text]>> endobj 74 0 obj <>/Font<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]>>/Type/Page/StructParents 40/BleedBox[0 0 595.26 782.337]>> endobj 75 0 obj <>stream hެ;]s?FrU?7? ?\ LH?|?Uɒl????DƉ?r??]??iw?^`M?I???tO?3?ؕ\q?X;_??????y????/?]?x??4??z?????M??U?;???????}????]}??o???}w???ɳ???8??;?iq?????LmY?Z]??,??????Z ??? ԕu?>???:w????{?-xG"?????8??f?T????\%?V$}?uۚ?I???}+>-????+=??\??s??S?I.?^-0?IOH??M??l??۽v{y ???y? d?`2?!`?L???o??HV??y?jy2;?H???z@???+h ??Ci???T\Ǭ?цЍ?L?M?,S `Y?X?5b??B??YAM????`G00?@[Rm ???^??f?y????Qg?> ??w??ð=??o??4??Ԡ 7 ??p[???+??8?!?7o!R+?iQ ?$?πW?Q?e?=ȿ??@T?p ???o?e?0'??ͺ^????;/???0??b;'?d?PYS??K?]2?!?ȍ???s??????vdk ?H?ɪ?,???ȫ?_X??VҾ????Xmp?y0B??]mA??z?#ks?]??y?N0??w???*s??'?? md???#n???s??o@?P?aM???"#????????????7??:?5?Rf?9]?Qp=4???؜?#???L8??}???m??oa?j`?xU???W?ߢ·#Ar??y??ف??]w?ڜ???kLwȓ???`wa@?U&B1?<$sq?.p?X%㮻?Y??ץa?????H?2?NJcc=?'h?;? ? m|?G???麔??5?.v?q???FO?9?Y?3w??ŝ? 6Ħ???+N??3?l?K?????a?F???[????:np?????=?w???????zH???? fO+?K]O?=Bȝ+=>?mW?????VȀ?:?j????;ڎ.??l??p ???(a?ݣ??9Ai??y=????ڠ?d̨???? cZ?h?lM|?!?z.?\?X"N????\??&?uyai?F?????????v(????? ?? ??????%?x?;???#"??d???G?ŧ???ƃcy???#?s?2?9d?cmb 9??}XrPu??˄tU?-??Ьe?c6?Jk? ??E??&?P-y^T?8??X/_=?ͫ7???r???(??ї??????7Բg??Y;??h??DDb0?)?hP|?G? *?? >?%ep?K??b??]?q]+?p?t?+?${b?0??(i??#???:?`?`??6.??:u??L|??vÁ#?w?H^ ?#Q?aU??,??ĭŎ??TM?{??ev?^T'?׹K}DŽ^m?7a?1՚)BĨ??lgM??????H6?Y?-??]??d?Z??t af???p???uy?`??D??Q?H?0?%? .?w??tt?u?NĹ?Q?b???`,?%_F???)/#?0?#?6??>?1gn?n??uNH???? ???+?;?[O????d?I?e?? ?????Β?U1$7?h?aE?0??``@m?L??????L??Ƙ?c?"?c"?b?D???????$?M3?c0?3?;???GƉ??0.????????`t?|??7 ?1??Nk?A큽??w??iD{u2?6ی?[???׭??uFY?~?1?r^8????d?c?pk?X??B?idheR?.?R??%?D??`?%??????R???L?둒D?^??ȑG"*??I?UX??W"? !ʔ\?S??1V????H??`l????e?????v?i??cU*???Y?Q???/v}????? ?p??8 {R?G/????????{Ѡ?öB?I??γ?I:5?|p????>B?ژT??L????܍2Z??%????2ϵ?E??8XD_?;|j֦V0??9"R??`@Л?,?????b????D?|Ɣ??7??p?­?͏2)e1f:_~?H??W ???1??T?}CJL?)????@b.?M?ad?8J?????????A?QN? ??;?Vlq|_??^?D΂G:Z??0??u??=ҀY?9{ ?]?l07?R%X[W?BC?׎?????x-??T0?jx?????X!>>???+??gtp???\P?L?|?16?=\L?N?q;?l]?W??uT?3?"qS?5?2????????Y??[J??(2????kʎZ?+??|?ʻ?!??l?:e??~"?Dt՘ω? ?;?;????D??R???ɨw/?~vm-??1?*yX??x9?Г?^???AX!@-?u?Do?e?¸?TYET&?x_Q??kqZ???p?;&??=???&?????,]??΍^x̀??5?8?4?v}?3f$gz ??S???????ޥrfE???@?ګ??R?lQu]3???/P|?%r*\W?a?X???g?՜ ?=E#!?$?.oVM?Z???P;???2H^??? ?%?@oh??$???!??\?.????ド.?4???d"?!a>?f???>,:?Ny;\?3????????g?????vz2?qp??_?hF??ؙ?R??/1?g?c3:ְ?.H?oO??X?!t??I?8??f?j????O?x=s endstream endobj 83 0 obj <>/Font<>/ProcSet[/PDF/Text]>> endobj 82 0 obj <> endobj 85 0 obj <> endobj 84 0 obj <> endobj 86 0 obj <>stream h?TP1n?0 ?? ? 2H6??𒢀?6E?tW$?PS-?}$?Mс$x?᎔??#A~?7=FY??/ln8:???Lܺ?ͤ?D??9????i??L?9? ??J??-??v?????~ ?'? ?,B??tx??,???????&?-?AdM#Bs??GB??g???`?5?ǦR????????y:0 s2W..??#|>%???r???h? endstream endobj 87 0 obj <>stream x?cd`ab`dd?????rt?v??? h??f?!?"?Ћ?????A2,U??~???"?=Bp?!&FƼb???ʢ???dMCKKs#K??Ԣ???<?Ē???? 'G!8?93??RA?&????J_???\/1?X/?(?NSG?>/Font<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/XObject<>>>/Type/Page/StructParents 43/BleedBox[0 0 595.26 782.337]>> endobj 91 0 obj <>/Border[0 0 0]>> endobj 92 0 obj <>/Border[0 0 0]>> endobj 94 0 obj <>/Border[0 0 0]>> endobj 89 0 obj <>stream hޔْ?6?]_?Gh???l*U>2?S?ıU?[5?%A#ƔȈ??N?u?????C?d?J?@???7?????o?^?y5???ū???燶??_j{?6(?y[T{???{9}h&/???h*???$ ?i??Q?1f??4P?t???????'???N?]L???;??-C? ?L?$????Z|7????#??A? ??9?7??O? J"8?xś$n????U??? f?,?????k?????ש ?,?>Ne8??????DN???7???S{L?????t?#?n?&???????g???x8l?ʒ??mbҐ??( ?媴??$ L?????NN_U?˼F?;Dj N?,LO???@?i'L?r???4?ɚ) X??܄i ɂ??U???g?\??}?I%??SagR???\?a??j?#?a C?K??y`D?WF?QR??????-C#???????.??????b??p?u??m&>???A8?%?????'??Y?wA?1/ߋ3F/A< ??(??D/,m;bMǫ???(GX?o???:.bQHV?b???D???E??ֶ??c?n?x???=6o???ojliW?,?X?f??ZK Ra??pz1S?e; ?$Jg?A?*?ӹ T??|'Q??mp3-ݚ?ա??jg??O?Z???L???KW?`3???ե%??????R?|iKZ"???ȞOw ?"????P??.?=?i???|?u??????ν?A,? ??vHZ?_???M?S|?b??̼???ؠ?xV???-Ic??gb {???& ?e񏑁9?PqH?2G?@?? 0.-?đ9?И?w^Q̀?>G,????ْ ??,?-Q???7֝۳?@F ? ?M %b?o?;0?/Le?:C???rБ??vŊ?@jնBBb?P?"?`?POr?-?0??Fb???_ݯ7????3?g????I?????S?z?'?.z@RL??? ?4t???ti4@?V?HNQ?Ai????h?5??H?E???:??+^c?W$GA????+A?o?ו1??;%??lC??W?c?????????s!{F??????Mٵ?^gUIj.?'{p?yk??N?x??????dpg?D:o???%?? *??Q?x? ?^???b?^'?w ?5E?u?(D0j.B?!wK?qMb??L?w??#??І?!C???)?wD[? ?B??¡?qR?qIE???LE?"2?Dr/?????A?aĿfrYT%?фe???A????)?Wܒ?w?0???]??ϯ8?8x?????s?/<7`??懦???ms?RW?ͷ???mH??M?!?e7?0P?};J7!?(˺4 !? !?w???+sf?aD??#?d???yC????R??hi?1??xl?m?z?_???!>?V)?*/K????H????V ==\^?`?_????-o?0tQ?+?:?zp??$?E?{?^pi̾ ~?@藗$c?~ݧT~?????Ϥu?I?????LA!?l n**ID?*???He ,?id????I??IJ?Ug??S`g?ٺPrX\?Ţ?h??&3H8?)N ??>D?l?a?xt?q? Tz?x?p??*?j?^?l?f?3f?+??+?M.3??7MF̚sf?o?F^?lw?f?sf!;H?5?f?y?TiY?笪 h??e?;u?2~s??J}?)??ۦ???P?h?+}?z??MG_?r~\?+c?8?8?}??a?骳 ?E.???>??m?.s?????@???U?Ƨ?'K??[s?o?z?H???H?[?I?p???F;}+Xm@UJ{1??%z?p1#?7?7jı??A??wP2X??^zl]??8??h?????C"u??U??S??x??mԦ?]w??V?z?|??)իZk??%NI??@t?שּׂi?T?L??u??R?@X6??V?+w???I?uU?L'??߼?þ??Ը??$6+D???r???k?6 %??+*)|Z?_j?r??\x~?D??֠?|?]???oeY਩?.- Ƶ{a???]^???z?x????y?? 'H??\+?nt???Y???co?Ʌ<3?@?r?!]??2???Bv???(???U??$*?G*????=???|?JM ?&?#?x?ɀ:A\<[???D? ?Xo???p??R#? RO??.o?g?*??Q(??F?? ?"??8Bƃ;?7??"? ?̶׎??????U7?? n`ryo63E??(?H??š???G?z HVZA??:?????0:s#sd??E?vr?Y?O?????b ~?*D??w?hK??:@???x?j????>?ܤ΋?c?83{K??5??h??x?G?Ҷ??v?;??$?wV????Lc?$?? ?????É?z?????wwC? ?Z?? ??? ?x?n??X\s?S?|?d???????????Lק}??S2)E?Q?@5??JG????'ҵH??#?x?%lS:??ֺ=[7???7?w&?V7??B?Tr?a$f?=NGzA?K???>???S%*?C?η??ˆ?wU?K??????????t??????d ??#???;??n+?z?u?q?}??:M[??'?@>?vw'?r?U???'1??T??p?=??k?冮?M??x?b)??ˣ?c??A???????6x??<G?zP??????9?l? *X?eQ?r8J?O?U?9?);׵?j???-ֶYH?[?^9?G??vq?aw????F??ą??\???CC???$(??J?6\;??k??9??fХ^??_`p??ZEޠp?W?/&Ͷ?g:a??nw ???s?#?^????K????D??@??????q??R???̛Ɖ??\?{?y????????z%j֫?*ĩ?|??E$?? Q??????_?UX"??)ݷtB?#pŅ ??@:cH?_;cOT4"?B???qe.4???/[?|d??;>Q?%~??u??p?TG `+? ???ԩ)???ݽ??/\`*??q9 ,?P??0???y0??8ɸ???? J?????nn?9)?ծ?.??C??8??%?/?Ϡ??3? ?܉?0?&ޣ^ɳ?.\???x??s[Ne?yu???:#g?#s?>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>> endobj 96 0 obj <>stream ????Adobed????     "")""""""),))))),222222;;;;;;;;;;;;;;;%%2%##%2;2.,,.2;;;;;;;;;;;;;;;;;;;;;;;;;;;;;????"???   3!1AQa"q?2???B#$R?b34r??C%?S???cs5???&D?TdE£t6?U?e???u??F'???????????????Vfv????????7GWgw????????5!1AQaq"2????B#?R??3$b?r??CScs4?%???&5??D?T?dEU6te????u??F???????????????Vfv????????'7GWgw??????? ?????+阖?[?*ay?>k?>??????h?̢???Cۺw????\??h????ugߒ?p?l??t.g???wt>??2???Za????t???BK???UoX??g3?+>N???V?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)?N?????gثy0?Æ?YX%?ڕ??????m??[c??9?p?Ţc??4??\w???[9?h?xVS??[??طt??uN??????ʽ-W??b?;}5W[????i?????I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$;?+ƭ????4I'@?IY???˵?f?}????8?i????S3??>?W??c???E{c????5???w??M%?z0.?޽ߢF????:?z?~??d???%Q??*???tRYO?!????^6?w???'?t?2O?n?6n?}?~??=?\?~-??[:mO???????ǁRE??Op?h?????R????/??]$?p??[e??ߤw?[??Gh?z4 >ё???o?j"'?*??W.ߋ?????=v_?]?m??v??>?u? ????R5/հg???G?૗o??Ie????z??O?~??}?(???{?????6??6|d?=?\?~-??P?Ph?FF?ݻ????E=)???nE?V,?Z????'?\1??+?]?A%?r3?{,?( ??F?I?f??ٍE5?wH?:l{%I$?W)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJBʼcR???ƗG??(??V???S??JJp???uL??OLy?Ƈ4????F????????j????"?????S?~???V??z??n??????Z?RIO=?w??[????????????k?I%ϳ2?4?=;>@?/???_?k??W?}b??}?W?f??[?p?|#䒛?.k?T??R??>Q.[??Q(??M6 ~?S?.&??N?ɴ{O?SФ?ǵ?9??A)$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?/{ki{?5?I=?YtR??c??,~4?7F????J}a????5??Hy???I??X???ƈh?O?}J??5?.p?$??k?LD??Y?????lm????a`??NöÓ?_???Pvn??>??a??Z??g?3h???@?U'?쟒JzT?wI????8v??I??c??? E%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?S????N>???@???qt?!h,?gQ?V?ֻ??ٸ??-? -D??? !??*I$?????????f?4???υ????LK1+??o???R?}??i?e?$??????oP????????A???2??+(}@??}x?˽Sd{???,??j?ILPuf??"4칬_??b7?~аb??6??1?<7?WP?Jpr??f=?>???j?M??zf;??????U???m?nH??i-??ۂ?8]*I)???N???Q???n???Z???D?X??6?eL??s6R?\װY[????w?]I)?k??0Y?zu??z?a?hx{??=?~v?"???m؍??V?^2??`??g?V?I)f???S??JRI$??Ψ???ı???a`t???3??i???r????[??@?A?O?%??-??;?I$?b?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?$?I)I$?JRI$???I$?*?[???O??*کտ?_??????T?l?????B?YT?l?????B?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IO=???F?????.?s?_?k??W?}b?RR?I$???I%)$?INWV???Ո?????XvZ߃۪???]???=?G~e?^@O?.???T?S??~?`???k ????x????%m??G?buJ?ʙk<&>??b?????5??;???$????>????.v??5?S?)~?@???q?M?????+???=?9?PA?RS$?I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$????tL?s??ѝ?n? ?????hfא=?x)_?:?OCƻ??~`??H?/?]??o`?IO?????????????^2*??~uo?Z?ׅg?FfK??=2?NM??/o-????'? )??Y?W:?펟NY?6?v??^>N I%)$?IN}h??n??F?mt]????Z˱ ??Q?͗V`? x%???U????kd? 4k|վ?K21?U???A?~?$?Я ?A???W?d]?*얆???Hi3Ɓdg???Z??d???-?n?|???H?gMc???eΈ? W??|???;t?K4??7??L?+?r?T???͏[???kc^?Mos???}ZŢ???=?ZѰ~??|i:?3?Yu:?A-x?????q???,n?9?\?ˊ\Q???w??꤃??????R? ?K?l?̏Gt???D??b???8?????????k?_?H?)}?x?+???~??????~???l??c]?r? ??? '*?%oe?V턐? ??>*^?R:n???Vw????[c?-???z???elȭ???X?A???:9W??^M?2??hct??>PVOO?N?'??KZ?f?$i? ?t????K???."4+:F=??5?"??/|Q4 ??@=z????Sq??m?3q?{?:N??7՚k???e?6>c???%??3?U?:ZA??ú?Mǯ??P;Y??Os?J??M?/?z?hu???p"?h]?%??????czu ?7'`?? E:_,Q?JI$??$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)T??Я???IV?N?? ????Ԕ?????#a??W?R?????#a??W?R?JRI$???I$?$?I)I$?JRI$???I$?$?I)I!deU?????CA&5v?|?~?L??P????F??:H6?;?~??3i~??N?@??[?TUi?@ne/??@????R??w-/??? ?U??LL?ٿ??RvuM?'?????Xl$??ڙ?I?D?;???SI?i:]?TSi?@9?D??????uq`?? ?Zt??S??O??4?~w?J??6@vel??i?]??$?ebG?G}r~\y?Zt?c?KH?\?????~<"ё^Cw???? ??E6?$?AJI$?R?I܊?-k?v???5??%$IW?6?????-p$?>!???EV?%Tx'???5???)?J?'C??F?;c???%Pxc????)?O?'??R???l???Fȝ?????_?y?????%3I@Xt??HXL{N??????=?? I??q=??4??*?A??u???f?v??N???????J???I$???I$?$??gՄ?e??b@????j?.$?? ||ǒ4wU?I ?t????B?c??I??P?$I ??? ?#??;m&=????4??!???O??H?t?=??)IP6>??$^D?N?)?J??O1??Ky???v??S4?=C?????ʹ???3?|ҥ$I Z?? ?O?!a??F???J??$?P???{}?̈́O????6Z]0׍???:e"+un??I%)$?IO=???F?????.?s?_?k??W?}b?RR?I$???I%)$?IJI$?R?I$???Y{v?=?е?A????C?N6?K߄?~?????ati$??????+???X??Fh?????:?#?M?????_ |'C???v?͵ݠ??{53O??$?W?2????o?6??????T?L??MO*xD[^r4ڧ*?ݱ??y?m?K??~??[[??W???6`???&J?x????5h ?????h?P?$??<Ž?y%^Ko? ?l? ??`???7lBn?????u???[???1??\\43???tZK/???ۊ.aq7?? mtO??F_,Q?JI$??$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)$?IJI$?R?I$???I%)T??Я???IV?N?? ????Ԕ?????#a??W?R?????#a??W?R?JRI$???I$?$?I)I$?JRI$???I$?/????!?ĘT_?~D?? ^???ݰ>?G? U32>?y??7Q[?wT[??y?W+~y,ea????????H??Oᡮ?n????)?m??????>????Ztj??a??S???;??n?/???ݫ????L]?v?m[?!?????????????M?N?????:|???@?????Ӑ??w?Mk????mS??$???Ο/???~??~g?%?????_j?n|??uQ??$;?????"??0??h??{??~ Z???*???$?Ο??????=Q??{?i/?_j???n?U????v?ITΠ =GTF?o?ug?m??Nӟ-?*?P??_?v??&??g??}'??C?6????+?Z?u???????????Re}B??O???k????5?>)Rz???_K?????~f?/??F?ҟMۣw???K?U}????9T?Q?O?߽?_$?????T ???ӥ??N?G?$GQ?i?K??????F??>?vHw????K?U}??^y?=;+??N???]g?VמK?;+???ӣ?<y=??u?zF???w?????L?۲w}????????TkϓW?#????~??M?>D?\z??i?k?y?^i8gɃTz?4w?=???$џ"MQ?????????د?UU?6z?Va?/??Y??k?Ϥ0?`?????G?I??W??c ???????@?Z͏??k??!???J?X???i???7v??Q?+6???SZ @??H;^|???v???-??滃??4뭩?j?g?7??{???7???⚑??Gꚿ?Ԁ??m?*A?ӫ?T???????j?ϖo}p??iֿ??wC?Wڪ??!??S???;??͏???kz?Ϊ}#:;??????zj???ef7g?G?wM]]@o??C:??H???_j?ޣk??HD?;????V??Ş??????;??~?/?=B?\?Di?{???>I?OP ???} ??;???$??W?????zf?Y??w???%cs??Tz??!??~t?+?5?g?g?e`??2Z}?H?{%mY????If?i?????{%?*?????Ҫ=_?χ???n|?s??Q۠;????^)?Vq.?c64?[????|R???8??g??????y??+?UL???Q??R?~f߇t?W??Q?k??N??;^*L?4ﱄ ]??o?x????k?-a???????;??+?Y???_V?H?????[??Ǩ??i?k?@??x???????s}?ǰ?ƷV?u2?3???2k????\????q?m?i??5 7^L1??[n??F?ȪyX?bs?(?w?w?????6[GO??7kX??{?kD????"G?o?ƫ??? _5G???V??l?8c?9?gp> ?QHR?gRa{k? ?k%????'????u???إՆ?e?2?4D?r ???步?=??Ű????p?;???E?????[????9c?u?????